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Virtual Screening of Antidiabetic Plant Phytochemicals for Analogues that Cause Beta Cell Regeneration

Kyalo, Cynthia Wayua; Otieno, Filex; Munene, Samuel; Kagia, Richard Kagia (AFRICAN JOURNAL OF PHARMACY AND ALTERNATIVE MEDICINE, 2024-08-08)

Immune-mediated destruction of functional beta-cell mass is the key mechanism for pathogenesis of type 1 diabetes mellitus. Currently, the mainstay conventional treatment for Type 1 Diabetes Mellitus is use of exogenous ...
Whole exome-seq and RNA-seq data reveal unique neoantigen profiles in Kenyan breast cancer patients

Wagutu, Godfrey; Gitau, John; Mwangi, Kennedy; Murithi, Mary; Melly, Elias; Harris, Alexandra R.; Sayed, Shahin; Ambs, Stefan; Makokha, Francis (Frontiers in oncology, 2024-12-11)

Background: The immune response against tumors relies on distinguishing between self and non-self, the basis of cancer immunotherapy. Neoantigens from somatic mutations are central to many immunotherapeutic strategies ...