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Pharmacokinetic and pharmacodynamic profiling of compounds similar to paracetamol from zinc database: an in silico analysis
(F1OOO research, 2023-06-21)Introduction: Paracetamol is the most used drug for the management of pain and as an antipyretic through its mechanism of action on Cox 1,2 and 3 receptors. Paracetamol is a lipid-soluble molecule that can pass through ... -
Virtual screening of zinc compounds similar to NSAIDS with better pharmacodynamic and pharmacokinetic profiles
(F1OOO research, 2023-04-26)BACKGROUND: Pain is a common symptom that is managed in both outpatients and inpatients. There are many side effects associated with opioids such as respiratory depression, constipation, hyperalgesia, and tolerance. ... -
Virtual screening for chemical analogues similar to phytochemicals that inhibit aldose reductase in the development of diabetic microvascular complications
(F1OOO research, 2023-03-21)Background: The polyol pathway contributes to the development of diabetic complications but can be inhibited by plant phytochemicals. This study aimed at assessing analogs of specific flavonoids that delay onset of ... -
Ethnomedicinal Review of plants utilized by the Abagusii People of Western Kenya
(2023)ethnic groups of Kenya use plants for medicinal purposes, and over 90 % of Kenyans have used medicinal plants once in their lifetime because they are accessible, affordable, and associated with fewer side effects. The ... -
Stability studies of reconstituted oral amoxicillin suspension (125mg/5ml) under different temperature storage conditions
(Journal of research medical and health sciences, 2022)The research objective was to determine the physical stability and concentration of amoxicillin reconstituted oral suspension (125mg/5ml) stored under room temperature of 25°C and refrigeration temperature of 2-8°C for day ... -
Role of NO/cGMP/kATP pathway on diosgenin induced antinociceptive activity by formalin and hotplate induced model in rats
(Indian Journal of Experimental Biology, 2023-05)Diosgenin is a natural steroid sourced from plants and exhibits good analgesic and anti-inflammatory activity. However, mechanism of action associated with the analgesic activity of diosgenin is not yet delineated. Hence, ... -
Identification of potential compounds for the management of multidrug-resistant tuberculosis using computational methods
(F1OOO research, 2023-03-20)and is spread through the air. Multidrug-resistant tuberculosis (MDR TB) has become a global health concern. This study focuses on developing alternative compounds to Levofloxacin, Moxifloxacin, Bedaquiline, Kanamycin, ... -
In vitro Antimicrobial Activities, Qualitative Phytochemical Screening, and Free Radical Scavenging Capacities of Gymnanthemum myrianthum
(European Journal of Pharmaceutical Research, 2023-06-05)Various members of the genus Vernonia are commonly used in traditional medicine to treat fever, malaria, diarrhoea, dysentery, hepatitis, cough, fertility inducer and as a laxative. Vernonia myrianthum (Gymnanthemum myrianthum) ... -
Determination of pharmacological activity of bioactives in Allium sativum using computational analysis
(F1OOO research, 2023-02)Introduction: Use of natural products for management of diseases has increased widely due to the belief that natural products are less toxic than conventional medicines. Natural products have been utilised for management ... -
Antimalarial Usage and Associated Symptoms Among Malaria Patients Seeking Treatment at Makongeni Health Centre, Homa Bay County, Kenya
(AFRICAN JOURNAL OF MEDICAL BIOSCIENCES, 2023-05-11)Malaria remains one of the most fatal diseases caused by plasmodium parasites in Sub-Saharan Africa. The disease is characterized by symptoms and resemble the flu, including fever, headache, vomiting, and among others. ... -
PHARMACEUTICAL PARTNERSHIPS FOR INCREASED ACCESS TO QUALITY ESSENTIAL MEDICINES IN THE EAST AFRICA REGION
(THE SCINNOVENT CENTRE, 2019-12) -
PHARMACEUTICALS INVESTMENT PROFILE KENYA
(Vanessa Finaughty, 2020)
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